Catalytic Health

7 Special Supplement, May 2023 • Canadian Allergy & Immunology Today patients and 77% in the patients who were uncontrolled despite treatment. Overall RCAT scores improved from baseline by 55% in patients with asthma and 62% in patients with urticaria (P<0.0001; Figure 3). In patients with urticaria, congestion frequency improved by 90% and symptom control improved by 94%. Overall RCAT scores also improved by 54% in patients with eczema/ atopic dermatitis, 40% in patients with nasal polyps, and 52% in patients with no comorbidities (P<0.0001; Supplemental Figure S3). After four weeks of treatment, the patient VAS score improved 3.9 units to a mean (SD) score of 2.6 (2.2) and the clinician VAS score improved 4.6 units to a mean (SD) score of 2.0 (2.2; Figure 4), indicating partially controlled symptoms. D I S C U S S I O N The symptoms of AR impact patients across multiple domains and can significantly affect their daily lives. The AR patient journey typically includes self-treating with OTC medications, often resulting in unsuccessful symptom control and treatment dissatisfaction. 1,3 Tracking symptom control and patient responses to treatment over time can be difficult as objective measures of AR symptoms are not typically conducted in real-world clinical settings. The measurement-based care used in the ICAR study quantitatively demonstrated that the second-generation antihistamine rupatadine improved bothersome AR symptoms for patients who were naïve to treatment, who were uncontrolled Figure 3. RCAT results at baseline and after 4 weeks of rupatadine treatment in (A) patients with asthma and (B) patients with urticaria. *P<0.0001 vs baseline. Error bars represent standard deviation. 25 (2.8)* 62% 90% 78% 55% 51% 35% 94% 15 (4.4) 4.0* 4.4* 4.6* 4.4* 3.9* 3.8* 2.0 3.3 3.0 2.8 2.2 2.0 1 2 3 4 5 Average (SD) Baseline Improvement Average (SD) Follow up Overall RCAT Score How often did you have nasal congestion? During the past week… How often did you sneeze? How often did you have watery eyes? To what extent did your nasal and other allergy symptoms interfere with your sleep? How often did you avoid any activities because of your nasal and other allergy symptoms? How well were your nasal and other allergy symptoms controlled? (B) patients with urticaria 24 (3.9)* 55% 62% 59% 46% 44% 35% 58% 16 (5.0) 3.8* 4.3* 4.2* 4.1* 3.8* 3.5* 2.4 3.2 3.0 2.8 2.4 2.2 1 2 3 4 5 Average (SD) Baseline Improvement Average (SD) Follow up Overall RCAT Score How often did you have nasal congestion? During the past week… How often did you sneeze? How often did you have watery eyes? To what extent did your nasal and other allergy symptoms interfere with your sleep? How often did you avoid any activities because of your nasal and other allergy symptoms? How well were your nasal and other allergy symptoms controlled? (A) patients with asthma

• Cover