Catalytic Health

6 Special Supplement, May 2023 • Canadian Allergy & Immunology Today AR assessment after four weeks of treatment After four weeks of treatment, the overall RCAT score improved by 8 points to an average (SD) of 24 (3.8), corresponding to a 66% improvement (P<0.0001; Figure 2). Scores for all the individual RCAT items significantly improved (P<0.0001), with a 65% improvement in congestion frequency, a 61% improvement in sneezing frequency, and a 68% improvement in symptom control assessment (Figure 2). Overall RCAT scores improved from baseline by 67% in treatment-naïve patients, 64% in patients who were uncontrolled despite treatment, and 51% in patients needing treatment switch (all P<0.0001; Supplemental Figure S2). Scores for all the individual RCAT items significantly improved in all patient categories (all P<0.0001), and improvements were particularly notable (≥57%) for congestion frequency, sneezing frequency, and symptom control in all patient categories (Supplemental Figure S2). The improvement in symptom control was 86% in the treatment-naïve Satisfaction with Current AR Treatment Patient Category Patients, % Very Satisfied Not Satisfied Feel Awful Somewhat Satisfied Overall Naïve Uncontrolled Switch 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% Figure 1. Baseline assessment of patient satisfaction with current AR treatment. 8 30 46 16 15 16 37 32 2 29 53 16 7 37 46 9 Figure 2. RCAT results at baseline and after 4 weeks of rupatadine treatment. *P<0.0001 vs baseline. Error bars represent standard deviation. 24 (3.8)* 66% 65% 61% 47 % 44% 32% 68% 16 (5.2) 3.9* 4.3* 4.4* 4.1* 3.8* 3.6* 2.3 3.3 3.0 2.8 2.4 2.2 1 2 3 4 5 Average (SD) Baseline Improvement Average (SD) Follow up Overall RCAT Score How often did you have nasal congestion? During the past week… How often did you sneeze? How often did you have watery eyes? To what extent did your nasal and other allergy symptoms interfere with your sleep? How often did you avoid any activities because of your nasal and other allergy symptoms? How well were your nasal and other allergy symptoms controlled? Overall RCAT scores at 4 weeks, all patients

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